Endocrine Abstracts

Introduction: Liver transaminases are markers of parenchymal liver disease, most commonly non-alcoholic steatohepatitis (NASH), the inflammatory component of non-alcoholic fatty liver disease (NAFLD). Common causes include obesity and type 2 diabetes mellitus (T2DM), both common conditions in the UAE. The prevalence of NAFLD in this population is not known. We report data from a large diabetes centre including ALT and aspartate transaminase (AST) levels in patients with and wi...

Background: Obesity is highly prevalent in the Middle East. Treatment is a challenge and with an aging population, therapy in the elderly poses new problems. Published data on efficacy of bariatric surgery in the older age groups are scant.Aims: The objective of this study was to assess the outcomes of bariatric surgery (BS) in the elderly (≥65 years) in the UAE population.Methods: ICLDC patient database was accessed to ident...

Background: Interest is rising in the use of traditional food as potential treatments for diabetes. In some arid regions camel milk is believed to have special health promoting properties. Some studies have linked consumption of camel milk to diabetes prevention in addition to describing hypoglycaemic effects in those with diabetes. The potential mechanism is incompletely understood.Aims: To investigate the impact on glucose metabolism after a mixed meal...

Background: Down Syndrome (DS) is the most common chromosomal abnormality. Obesity and type 1 diabetes mellitus (T1DM) are known to be more prevalent in patients with DS than the general population. Available data on the prevalence of type 2 diabetes mellitus (T2DM) in DS is scant.Objectives: This study aims to investigate the prevalence of obesity and diabetes mellitus (DM) in adults with DS seen in Imperial College London Diabetes Centre (ICLDC) in the...

Camel milk provides a modest portion of the overall global milk share but is an important source of protein in arid regions. Perceived health benefits include anti-diabetic properties attributed to its unique composition. We hypothesise that exogenous insulin present in camel milk mediates a hypoglycaemic effect. In a randomised, double blind crossover study, eleven normoglycaemic individuals were allocated to receive a 300 kcal pre-load of camel milk or cow milk ten minutes p...

Introduction: Bariatric surgery (BS) is currently the most effective treatment for obesity. However, weight regain is a recognized challenge in post-surgical management. Drug treatment for weight regain after bariatric surgery has been used, but little published data is available on their efficacy. We have investigated the use of Liraglutide for relapse after BS in an Emirati population.Methods: ICLDC patients with a previous history of bariatric surgery...

Background: Type 2 diabetes (T2D) and obesity have been linked with sleeping disorders in general and obstructive sleep apnoea (OSA) in particular; both are highly prevalent amongst Emirati patients. However, little information is available in this population regarding the prevalence and symptomatology of OSA, its relationships with T2D and obesity, and its impact on health outcomes.Objectives: This study aims to investigate the risk of OSA based on the ...

Background: Efficacy of bariatric surgery (BS) in obesity management is well-established. The super-obese (BMI >50 kg/m2) as a subgroup may have specific phenotypic and genotypic characteristics. Prevalence of complications and risks of interventions may also be different in this group.Aims: We have investigated BS outcomes and compared effects of different operations among the superobese in an Emirati population.Methods...

Introduction: Osteoporosis is an important cause of morbidity and mortality in older men, but the extent of the problem amongst Emiratis has not been previously reported. A screening programme has been in place for older men in a large diabetes centre in the UAE, allowing patients over age 70 to have DEXA scans; we have investigated the prevalence of osteoporosis and osteopenia in this population.Methods: Data on 179 consecutive patients with type 2 diab...

Background: Prevalence of obesity and diabetes has increased significantly in the UAE over the last 40 years. Adenovirus 36 (Adv36) infection has been associated with obesity in several studies across different ethnic populations, and usually is associated with improved glucose tolerance.Objective: 1) Identify the prevalence of Adv36 seropositivity among adults living in the UAE.2) Investigate the association of Adv36 infection wit...